Comparison of the CT and Pathologic Findings of Pulmonary Fat Embolism Induced by Triolein and Oleic Acid in Rabbits.
10.3348/jkrs.2006.54.2.79
- Author:
Hye Won BAIK
1
;
Seung Min YOO
;
Hwa Yeon LEE
;
In Sup SONG
;
Hyeon YU
;
Jong Beom LEE
;
Yang Soo KIM
;
Byung Kook KWAK
;
Hyung Jin SHIM
;
Kun Sang KIM
;
Yong Chul LEE
;
Tae Jin LEE
;
Dong Wook SUNG
Author Information
1. Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Korea.smyoo68@hanmail.net
- Publication Type:Original Article
- Keywords:
Embolism, fat;
Embolism, pulmonary;
Lung, CT
- MeSH:
Diagnosis;
Ear;
Edema;
Embolism, Fat*;
Glass;
Hemorrhage;
Necrosis;
Oleic Acid*;
Pulmonary Embolism;
Rabbits*;
Triolein*;
Veins
- From:Journal of the Korean Radiological Society
2006;54(2):79-86
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate the CT findings of pulmonary fat embolism syndrome that was induced by triolein and oleic acid, along with its pathologic correlation. MATERIALS AND METHODS: 16 rabbits were included in this study. The rabbits in group I (n=8) were embolized with 0.2 mL triolein and the rabbits of group II (n=8) were embolized with 0.2 mL oleic acid through ear veins. HRCT scans were done prior to embolization and at 0.5, 4, 24, 48 and 72 hours post-embolization. The pathologic correlations were determined at 0.5, 24, 48 and 72 hours. RESULTS: At 24 hours, one group I rabbit showed abnormal CT findings that were composed of several 2-3 mm nodules and multiple ill-defined peripheral ground glass opacities. The pathologic finding of this rabbit at 48 hours was mainly intraarveolar edema. All the group II rabbits (n=8/8) showed ill-defined bilateral and peripheral ground glass opacities with (n=6/8) or without consolidations (n=2/8) on the 0.5 hour CT. All the rabbits (n=7/7) showed that the new ground glass opacities and ground glass opacities noted on the 0.5 hour CT were changed into consolidation. The margins of the ground glass opacities and consolidations were more sharpened on the 24 hours CT. All 6 rabbits (n=6/6) showed consolidations without ground glass opacities and the margins of the consolidations were more sharpened on the 48 hours CT. There was no significant interval change on the 72 hours CT. The pathologic findings of ground glass opacities were interstitial edema or mild intraalveolar edema. The pathologic findings of consolidation were intraalveolar edema, hemorrhage and coagulation necrosis. CONCLUSION: The CT findings after fat embolization using triolein and oleic acid were ill-defined peripheral ground glass opacities with/without consolidations. These findings occurred in only one triolein group with the time lag, but these findings were immediately and extensively seen in all group II rabbits. These CT findings may be important for making a diagnosis of pulmonary fat embolism syndrome.
