Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica.
10.1016/j.apsb.2015.01.012
- Author:
Yang YU
1
;
Zhibo JIANG
1
;
Weixia SONG
1
;
Yongchun YANG
1
;
Yuhuan LI
2
;
Jiandong JIANG
3
;
Jiangong SHI
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Journal Article
- Keywords:
Caprifoliaceae;
Coxsackie virus B3;
Flower buds;
Glucosylated caffeoylquinic acid;
Lonicera japonica
- From:
Acta Pharmaceutica Sinica B
2015;5(3):210-214
- CountryChina
- Language:English
-
Abstract:
Three new glucosylated caffeoylquinic acid isomers (1-3), along with six known compounds, have been isolated from an aqueous extract of the flower buds of Lonicera japonica. Structures of the new compounds were determined by spectroscopic and chemical methods as (-)-4-O-(4-O-β-d-glucopyranosylcaffeoyl)quinic acid (1), (-)-3-O-(4-O-β-d-glucopyranosylcaffeoyl)quinic acid (2), and (-)-5-O-(4-O-β-d-glucopyranosylcaffeoyl)quinic acid (3), respectively. In the preliminary in vitro assays, two known compounds methyl caffeate and 2'-O-methyladenosine showed inhibitory activity against Coxsackie virus B3 with IC50 values of 3.70 μmol/L and 6.41 μmol/L and SI values of 7.8 and 12.1, respectively.
