Synthesis, potential anticonvulsant and antidepressant effects of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives.
10.1016/j.apsb.2015.01.008
- Author:
Xinghua ZHEN
1
;
Zhou PENG
1
;
Shuilian ZHAO
1
;
Yan HAN
1
;
Qinghao JIN
2
;
Liping GUAN
1
Author Information
1. Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan 316022, China.
2. Hailisheng Pharmaceutical Co., Lid., Zhoushan 316021, China.
- Publication Type:Journal Article
- Keywords:
2,3-Dioxoindolin-1-acetamide;
Anticonvulsant activity;
Antidepressant activity;
Pentylenetetrazole;
Synthesis
- From:
Acta Pharmaceutica Sinica B
2015;5(4):343-349
- CountryChina
- Language:English
-
Abstract:
A new series of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives were synthesized and evaluated for their anticonvulsive activity in a pentylenetetrazole (PTZ)-evoked convulsion model and antidepressant activity in the forced swimming test (FST) model. Eleven synthesized compounds were found to be protective against PTZ-induced seizure and showed the anticonvulsant activity. In addition, four of the synthesized compounds (4l, 4m, 4p and 4q) showed potent antidepressant-like activity. Among these compounds, compound 4l was found to have the most potent antidepressant-like activity, and significantly reduced the duration of immobility time at 100 mg/kg dose level when compared to the vehicle control, which is similar to the reference drug fluoxetine.
