Hydrogen sulfide prodrugs-a review.
10.1016/j.apsb.2015.06.004
- Author:
Yueqin ZHENG
1
;
Xingyue JI
1
;
Kaili JI
1
;
Binghe WANG
1
Author Information
1. Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
- Publication Type:Journal Article
- Keywords:
Controllable H2S prodrugs;
Gasotransmitters;
H2S prodrugs;
H2S-hybrid nonsteroidal anti-inflammatory drugs;
Hydrogen sulfide (H2S);
Hydrolysis-based H2S prodrugs
- From:
Acta Pharmaceutica Sinica B
2015;5(5):367-377
- CountryChina
- Language:English
-
Abstract:
Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, their chemical properties, and some of their potential therapeutic applications.
