Discovery of new hazimycin congeners from Kitasatospora sp. P07101.
10.1016/j.apsb.2015.07.010
- Author:
Nobuhiro KOYAMA
1
;
Hirofumi SATO
1
;
Hiroshi TOMODA
1
Author Information
1. Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan.
- Publication Type:Journal Article
- Keywords:
Hazimycin;
Isonitrile;
Kitasatospora;
Microbial metabolites;
Nitrile
- From:
Acta Pharmaceutica Sinica B
2015;5(6):564-568
- CountryChina
- Language:English
-
Abstract:
In an analytical study of microbial broths, the actinomycete strain Kitasatospora sp. P07101 was found to produce three new congeners, which were designated hazimycins B (1), C (2), and D (3), together with the previously reported hazimycin (renamed hazimycin A (4)). The structures of these hazimycins were examined using various spectroscopic methods including nuclear magnetic resonance (NMR), and the results revealed that 1-3 were analogues of hazimycin with the replacement of one of the two isonitrile groups in 4 by an NH-formyl group in 1, the two isonitrile groups and an amide group by two NH-formyl groups and a nitrile group in 2, and the two isonitrile groups and two amide groups by two NH-formyl groups and two nitrile groups in 3. Only hazimycin A exhibited moderate antimicrobial activities against Gram-positive bacteria and Candida albicans. These results indicated that the presence of two isonitrile groups in the hazimycin structure is essential for antimicrobial activity.
