Three new lignan glucosides from the roots of Scutellaria baicalensis.

Hailin Long; Haijing Zhang; Anjun Deng; Lin MA; Lianqiu WU; Zhihong LI; Zhihui Zhang; Wenjie Wang; Jiandong Jiang; Hailin Qin

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Three new lignan glucosides from the roots of Scutellaria baicalensis.

Author: Hailin LONG ¹ ; Haijing ZHANG ¹ ; Anjun DENG ¹ ; Lin MA ¹ ; Lianqiu WU ¹ ; Zhihong LI ¹ ; Zhihui ZHANG ¹ ; Wenjie WANG ¹ ; Jiandong JIANG ¹ ; Hailin QIN ¹
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1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Publication Type:Journal Article
Keywords: 3,4-Dibenzyltetrahydrofuran; Anti-osteoporotic activity; Baicalensinosides A–C; Labiatae; Lignan glucoside; Osteoprotegerin-activating activity; Roots; Scutellaria baicalensis
From: Acta Pharmaceutica Sinica B 2016;6(3):229-233
CountryChina
Language:English
Abstract: Three new lignan glucosides, baicalensinosides A-C (1-3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7'-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1-3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.