Progress and perspectives on targeting nanoparticles for brain drug delivery.
10.1016/j.apsb.2016.05.013
- Author:
Huile GAO
1
Author Information
1. Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Blood–brain barrier;
Brain targeting;
Dual targeting;
Intranasal delivery;
Nanoparticles
- From:
Acta Pharmaceutica Sinica B
2016;6(4):268-286
- CountryChina
- Language:English
-
Abstract:
Due to the ability of the blood-brain barrier (BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem. In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood-brain tumor barrier (BBTB), and nose-to-brain barrier. Delivery strategies are focused on overcoming the BBB, directly targeting diseased cells in the brain, and dual-targeted delivery. The major concerns and perspectives on constructing brain-targeted delivery systems are discussed.
