Molecular mechanism of bone absorption in osteoclast.
- Author:
Bingbing ZHANG
1
;
Jun PAN
;
Xiaoyan DENG
;
Jianhua ZHAO
;
Yuanliang WANG
Author Information
1. Key Laboratory of Biomechanics & Tissue Engineering , Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, China.
- Publication Type:Journal Article
- MeSH:
Bone Resorption;
Humans;
Matrix Metalloproteinases;
metabolism;
Osteoclasts;
physiology;
Osteoprotegerin;
physiology;
RANK Ligand;
physiology
- From:
Journal of Biomedical Engineering
2005;22(6):1283-1286
- CountryChina
- Language:Chinese
-
Abstract:
The physiological reconstruction of bone is strictly dependent on bone resorption. Bone resorption is believed to be a complicated molecular reaction process that occurs in the microcircumstance of bone tissue. A lot of enzymes and factors take part in this process, yet there are not enough data with reference to the activation of osteoclast, resorption of bone matrix, regulation of bone resorption. In this paper we review the importance of matrix metalloproteinases (MMPs) in transfer of osteoclast and degradation of bone matrix, and the function of receptor activator of NF-kappaB-ligand (RANKL) and osteoprotegerin (OPG) in regulation of bone resorption.
