Investigation on the properties of mitoxantrone-insulin conjugates lyophilized powder.
- Author:
Wensheng LIU
1
;
Zhirong ZHANG
;
Yuan HUANG
Author Information
1. School of Chemical Biology and Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing 100054, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antimetabolites, Antineoplastic;
administration & dosage;
chemistry;
Drug Carriers;
Drug Delivery Systems;
Drug Stability;
Insulin;
chemistry;
Mice;
Mitoxantrone;
administration & dosage;
chemistry;
Neoplasms;
drug therapy;
Powders
- From:
Journal of Biomedical Engineering
2006;23(1):90-92
- CountryChina
- Language:Chinese
-
Abstract:
In this study we prepared mitoxantrone-insulin conjugate wherein mitoxantrone was an anticancer model drug and insulin acted as its vector leading to tumor cells. The drug loading of the conjugate was determined to be 11.68%. Stability trials of the conjugate were carried out in different pH buffer solutions and mouse plasma under 37 degrees C which showed the stability of the conjugate in vitro. Lyophilized powder was prepared and its pharmaceutical qualities were assessed. The retained biological activity of the insulin within the conjugate, demonstrated by animal experiments.
