Fatty acid synthase and prostate cancer.
- Author:
Ke-Feng WANG
1
;
Bin WU
Author Information
1. Department of Urology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, China.
- Publication Type:Journal Article
- MeSH:
Biomarkers, Tumor;
metabolism;
Early Diagnosis;
Fatty Acid Synthases;
metabolism;
Humans;
Male;
Prostatic Neoplasms;
diagnosis;
enzymology
- From:
National Journal of Andrology
2008;14(8):740-742
- CountryChina
- Language:Chinese
-
Abstract:
The over expression of fatty acid synthase (FAS), a key enzyme in biosynthesis of fatty acid, can enhance enzyme activity and result in the malignant behavior, special material metabolism and energy metabolism of tumors. The expression of FAS is significantly higher in prostate cancer than in normal prostate tissues, which shows that FAS can be used as a marker in the early diagnosis of prostate cancer. The abnormally increased expression of FAS in prostate cancer may offer a new target for the drug treatment of the disease.
