Allotransplantation of Leydig cells increases serum testosterone in rats.
- Author:
Jie SUN
1
;
Cheng-Ren SHI
;
Ye-Bin XI
;
Wei-Yi LI
;
Huai-Yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Transplantation; Leydig Cells; cytology; transplantation; Male; Rats; Rats, Sprague-Dawley; Testosterone; blood
- From: National Journal of Andrology 2008;14(9):823-825
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the changes of serum testosterone after allotransplantation of Leydig cells in rats.
METHODSLeydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times.
RESULTSAfter allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old.
CONCLUSIONAllotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.
