Cyclooxygenase-2 and cyclooxygenase-2 inhibitors in prostate cancer.
- Author:
Song XU
1
;
Jian-Ping GAO
;
Wen-Quan ZHOU
Author Information
1. Department of Urology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Cyclooxygenase 2;
metabolism;
Cyclooxygenase 2 Inhibitors;
therapeutic use;
Humans;
Male;
Prostatic Neoplasms;
drug therapy;
metabolism
- From:
National Journal of Andrology
2008;14(11):1031-1034
- CountryChina
- Language:Chinese
-
Abstract:
Cyclooxygenase-2 (Cox-2) is over-expressed in prostate cancer (PCa) and involved in its development and progression by facilitating inflammatory response, reducing cell apoptosis, increasing angiogenesis and damaging DNA oxidation. Selective Cox-2 inhibitors suppress PCa growth through various channels and therefore have a promising application value in the management of prostate cancer.
