A Case of Acute Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2).
10.3343/kjlm.2006.26.3.223
- Author:
Jungwon HUH
1
;
Whasoon CHUNG
Author Information
1. Department of Laboratory Medicine, Ewha Womans University, College of Medicine, Seoul, Korea. JungWonH@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Acute lymphoblastic leukemia;
ider(9)(q10)t(9;
22);
Deletion of the short arm of chromosome 9;
t(9;
22);
Fluorescence in situ hybridization;
BCR-ABL
- MeSH:
Adult;
Arm;
Chromosomes, Human, Pair 22;
Chromosomes, Human, Pair 9;
Female;
Fluorescence;
Humans;
In Situ Hybridization;
Isochromosomes;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Precursor Cells, B-Lymphoid;
Prognosis
- From:The Korean Journal of Laboratory Medicine
2006;26(3):223-226
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
ider(9)(q10)t(9;22)(q34;q11.2) is an isochromosome for the long arm of a derivative chromosome 9 generated by a t(9;22), resulting from the deletion of the short arm of chromosome 9. It is known to be rarely observed in acute lymphoblastic leukemia (ALL) or lymphoblastic crisis transformed from chronic myelogenous leukemia. We herein describe a 26-year-old female patient with precursor B-cell ALL, cytogenetically characterized by ider(9)(q10)t(9;22). Fluorescence in situ hybridization analysis showed two ABL-BCR fusion signals on the derivative chromosome 9 and one BCR-ABL fusion signal on the derivative chromosome 22. Although a t(9;22) and a deletion of the short arm of chromosome 9 are known to be associated with a poor prognostic factor in acute lymphoblastic leukemia, a larger study is needed to determine the prognosis of ider(9)(q10)t(9;22) cases.
