Association of mating type switching/sucrose non-fermenting complex with prostate cancer.
- Author:
Jun YANG
1
;
Ji-hong LIU
;
Ben-yi LI
Author Information
1. Department of Urology, Tongfi Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. yangjun109@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Cycle Proteins;
DNA Methylation;
Genes, Switch;
Humans;
Male;
Prostatic Neoplasms;
genetics;
metabolism;
Receptors, Androgen;
Sucrose
- From:
National Journal of Andrology
2008;14(10):935-938
- CountryChina
- Language:Chinese
-
Abstract:
ATP-dependent chromatin remodeling by the mating type switching/sucrose non-fermenting (SWI/SNF) complex is a basic biological event in the body, which is required for all the key processes involved in DNA metabolism such as gene expression, DNA replication, repair, chromosomal recombination and mitosis. In the past few years, increasing evidence supports a crucial role of this complex in prostate cancer development and progression via multiple ways, such as cell cycle regulation, androgen receptor pathway and DNA methylation. The present paper briefly reviews the recent studies on the association between the SWI/SNF complex and prostate cancer.
