Association of gene polymorphisms of cytokine and cytokine receptor with type III prostatitis.
- Author:
Feng-Hua PENG
1
;
Jin-Rui YANG
;
Long-Kai PENG
;
Xu-Biao XIE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Gene Frequency; Genotype; Humans; Interleukin-10; genetics; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Prostatitis; genetics; Receptors, Interleukin-10; genetics
- From: National Journal of Andrology 2008;14(12):1069-1071
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of the gene polymorphism of cytokine and cytokine receptors in the pathogenesis of type III prostatitis.
METHODSWe genotyped 24 outpatients diagnosed with type III prostatitis and 51 healthy volunteer controls for the single nucleotide polymorphisms of 13 cytokines and cytokine receptors at 22 sites by Sequence Specific Primer -PCR (SSP-PCR).
RESULTSThe patients exhibited significantly higher frequencies of the genotypes of IL-10-819 T/T (62.5%) and IL-10-592 A/A (62.5%), the haplotype of IL-10 (-1082/-819/-592) ATA (75.0%) and the diploid genotype of IL-10 (-1082/-819/-592) ATA/ATA (62.5%), than with the healthy controls (31.3% , 31.3%, 25.0% and 31.2%) (P < 0. 05).
CONCLUSIONOur data suggested that anti-inflammation cytokine IL-10 gene polymorphisms were associated with the pathogenesis of type III prostatitis.
