Updated roles of adrenergic receptors in prostate cancer.
- Author:
Heng-Quan LUO
;
Xiang-Xing KUANG
;
Ben-Yi LI
- Publication Type:Journal Article
- MeSH:
Adrenergic Agonists;
pharmacology;
Adrenergic Antagonists;
pharmacology;
Apoptosis;
Humans;
Male;
Prostatic Neoplasms;
metabolism;
pathology;
Receptors, Adrenergic;
drug effects;
physiology
- From:
National Journal of Andrology
2014;20(4):372-376
- CountryChina
- Language:Chinese
-
Abstract:
Adrenergic receptors are members of the G-protein coupled receptor superfamily. Recent studies revealed that these adrenergic receptors are playing an important role in the growth and metastasis of prostate cancer cells. The expression of adrenergic receptors rises significantly in prostate cancer cells and tissues. Agonists of these receptors promote the growth and mobility of prostate cancer cells, while antagonists may suppress their proliferation, trigger their apoptosis, and inhibit their metastasis. Clinically, receptor antagonists can significantly reduce the risk of prostate cancer and improve its prognosis after androgen depravation therapy. This article presents an overview on the roles of adrenergic receptors in prostate cancer.
