Relationship between ERCC2 single nucleotide polymorphisms and male idiopathic infertility in Ningxia.

Author: Chun-Lian LIU ; Hai-Yan JIAO ; Qiang MA ; Xing WU ; Shao-Tong JIA ; Wan-hong JING ; Qing-Hu YANG
Publication Type:Journal Article
MeSH: Adult; Case-Control Studies; China; DNA Repair; Genotype; Humans; Infertility, Male; genetics; Male; Polymorphism, Single Nucleotide; Xeroderma Pigmentosum Group D Protein; genetics
From: National Journal of Andrology 2014;20(5):419-422
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms (SNPs) rs13181, rs1618536, and rs1799793 on male idiopathic infertility in Ningxia, China.
METHODSUsing MassArray, we conducted a case-control study and genotyped three ERCC2 SNPs rs13181, rs1618536, and rs1799793 for 351 males (aged 31.0 +/- 4.2 years) with idiopathic infertility and another 327 normal fertile men (aged 33.0 +/- 5.9 years) as controls.
RESULTSThe ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility (OR 0.414, 95% CI 0.176 - 0.970), while the three single ERCC2 SNPs rs13181, rs1618536, and rs1799793 showed no significant differences between the cases and controls (P > 0.05).
CONCLUSIONThe ERCC2 SNPs rs13181, rs1618536, and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia, contributing to the risk of the disease.