Primary testicular yolk sac tumor: clinicopathological study of 8 cases.
- Author:
Fei-Fei LIU
;
Jian-Jun WANG
;
Qin SHEN
;
Bo YU
;
Zhen-Feng LU
;
Heng-Hui MA
;
Qun-Li SHI
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Endodermal Sinus Tumor; metabolism; pathology; therapy; Humans; Immunohistochemistry; Male; Neoplasms, Germ Cell and Embryonal; metabolism; pathology; therapy; Orchiectomy; Rare Diseases; metabolism; pathology; therapy; Testicular Neoplasms; metabolism; pathology; therapy; Young Adult
- From: National Journal of Andrology 2014;20(5):435-438
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathological characteristics, diagnosis and treatment of primary testicular yolk sac tumor (YST).
METHODSWe studied 8 cases of primary testicular YST by microscopy and immunohistochemistry.
RESULTSThe 8 cases of primary testicular YST, including 2 consultation cases, were confirmed from 1998 to 2013, accounting for 10.7% (8/75) of all the testicular germ cell tumors diagnosed in our hospital. The patients ranged in age from 7 to 43 years, 23.9 years on average. The main clinical manifestation of the patients was painless unilateral testis swelling. Microscopically, reticular tissues, schiller-duvaI (S-D) bodies, and eosin-stain transparent bodies were seen in the tumors. One of the cases was confirmed to be simple YST, while the other 7 mixed YST. AFP was a characteristic immunophenotype marker of the tumors.
CONCLUSIONPrimary testicular YST is a rare malignancyr with poor prognosis. Its diagnosis depends on preoperative AFP test and postoperative pathology. Comprehensive treatment, including orchiectomy, chemotherapy, and radiotherapy, can prolong the survival of the patients.