Association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with male infertility.

Author: Jian-Zhong CHEN ; Sheng-Min WU ; Gui-Xiang JI ; Ai-Hua GU
Publication Type:Journal Article
MeSH: Adult; Case-Control Studies; DNA Glycosylases; genetics; Genotype; Humans; Infertility, Male; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Semen Analysis; Young Adult
From:National Journal of Andrology 2014;20(6):518-522
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphism with semen quality and the risk of male infertility.
METHODSThis case-control study included 620 idiopathic infertile patients and 385 normal fertile controls. We determined their genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and analyzed their semen quality by computer-aided semen analysis (CASA).
RESULTSThe individuals with OGG1 326 Cys/Cys showed significantly lower sperm motility and concentration ([52.1 +/- 26.7]% and (3.75 +/- 0.91) x 10(6)/ml, ln transformed value) than the Ser/Ser carriers ([59.0 +/- 21.8] % and (4.12 +/- 0.88) x 10(6)/ml, ln transformed value) (P < 0.05). The risk of male infertility increased 69% in the OGG1 326Cys allele carriers as compared with the Ser carriers (OR = 1.69, 95% CI: 1.24 -2.31).
CONCLUSIONOGG1 326 Ser/Cys polymorphism might contribute to the risk of male infertility in the southern Chinese population.