Lung adenoma development and NK activity in mice treated with multiple carcinogens.
- Author:
Yun Sil LEE
1
;
Jeong Sun SEO
;
Hun Taeg CHUNG
;
Kyung Ja CHO
;
Ja June JANG
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Wide-spectrum carcinogenesis; Multiple carcinogens; Lung adenoma; NK cell activity
- MeSH: *Adenoma/chemically induced/immunology; Animals; Diethylnitrosamine/pharmacology; Female; *Killer Cells, Natural/drug effects; *Lung Neoplasms/chemically induced/immunology; Methylnitrosourea/pharmacology; Mice; Phenobarbital/pharmacology; Random Allocation; Urethane/pharmacology
- From:Journal of Korean Medical Science 1992;7(1):1-5
- CountryRepublic of Korea
- Language:English
- Abstract: A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).
