Technetium-99m HM-PAO SPECT in patients with delayed neurologic sequelae after carbon monoxide poisoning.
- Author:
Il Sang CHOI
1
;
Myung Sik LEE
;
Young Jin LEE
;
Jin Ho KIM
;
Sung Soo LEE
;
Won Tsen KIM
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: 99mTc-HM-PAO SPECT; Hypoperfusion; Delayed neurologic sequelae; Carbon monoxide poisoning
- MeSH: Adult; Aged; Brain Diseases/etiology/*radionuclide imaging; Carbon Monoxide Poisoning/*complications; Female; Humans; Middle Aged; Organotechnetium Compounds/*diagnostic use; Oximes/*diagnostic use; Predictive Value of Tests; Technetium Tc 99m Exametazime; Time Factors; *Tomography, Emission-Computed, Single-Photon
- From:Journal of Korean Medical Science 1992;7(1):11-18
- CountryRepublic of Korea
- Language:English
- Abstract: We used single photon emission computed tomography (SPECT) with technetium-99m hexamethylpropylene amine oxime (99mTc-HM-PAO) in 14 studies on 6 patients with delayed neurologic sequelae from carbon monoxide (CO) poisoning to determine whether any changes in cerebral blood flow could be correlated with clinical or computed tomographic evidence of delayed deficits. Among the six initial CT brain scans, two showed low density of both basal ganglia and two showed decreased density of the cerebral white matter. There was no correlation between the clinical outcome and the findings of the follow-up CT brain scans. Of the two SPECTS with 99mTc-HM-PAO performed during acute anoxic insult, one showed focal hypoperfusion which appeared 20 days prior to the onset of delayed neurologic sequelae after CO poisoning. Seven SPECTs in the six patients performing the delayed phase showed diffuse patched patterns of hypoperfusion which improved on follow-up images. There was good correlation between the clinical outcome and the findings of the 99mTc-HM-PAO SPECT. In preliminary conclusion, 9Tc-HM-PAO brain SPECT can be used for predicting or evaluating the outcome of delayed neurologic sequelae after CO poisoning. Cerebral vascular changes may be the possible cause of hypoperfusion in patients with CO poisoning.
