Long-term Outcomes of Medical Therapy Versus Coronary Revascularisation in Patients with Intermediate Stenoses Guided by Pressure Wire.
- Author:
Hongyu SHI
1
;
Chi Hang LEE
;
Mark Y Y CHAN
;
Adrian F LOW
;
Swee Guan TEO
;
Koo Hui CHAN
;
Rishi SETHI
;
Arthur Mark RICHARDS
;
Huay Cheem TAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aspirin; therapeutic use; Coronary Stenosis; complications; diagnosis; therapy; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; methods; Platelet Aggregation Inhibitors; therapeutic use; Retrospective Studies; Ticlopidine; analogs & derivatives; therapeutic use; Treatment Outcome
- From:Annals of the Academy of Medicine, Singapore 2015;44(5):157-163
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONThis study aimed to examine the long-term clinical outcomes of coronary fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) in a real-world population in an Asian tertiary centre.
MATERIALS AND METHODSAll patients who underwent FFR measurement for intermediate coronary lesions in our centre from June 2002 to December 2009 were enrolled. A threshold of FFR ≤0.75 was used for revascularisation. All the patients were prospectively followed-up for major adverse cardiac events (MACE) of death, myocardial infarction (MI), target vessel revascularisation (TVR) and stent thrombosis.
RESULTSBased on FFR measurement, 368 (57%) patients were treated medically while 278 (43%) underwent revascularisation. At a mean follow-up duration of 29.7 ± 16 months, 53 (14.4%) patients in the medical therapy group and 32 (11.5%) patients in the revascularised group experienced MACE (P = 0.282). There were no statistical differences in all the clinical endpoints between the 2 groups.
CONCLUSIONMedical therapy based on FFR measurement is associated with low incidences of MACE at long-term follow-up.
