Etv5, a transcription factor with versatile functions in male reproduction.
10.5653/cerm.2012.39.2.41
- Author:
Jinwon EO
1
;
Haengseok SONG
;
Hyunjung Jade LIM
Author Information
1. Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea. hlim@konkuk.ac.kr
- Publication Type:Review
- Keywords:
Etv5;
ETS transcription factor;
Testis
- MeSH:
Animals;
Female;
Gene Expression;
Germ Cells;
Humans;
Infertility;
Male;
Mice;
Phenotype;
Reproduction;
Stem Cells;
Testis;
Transcription Factors
- From:Clinical and Experimental Reproductive Medicine
2012;39(2):41-45
- CountryRepublic of Korea
- Language:English
-
Abstract:
Transcription factors govern diverse aspects of cell growth and differentiation as major switches of gene expression. Etv5, a member of the E26 transformation-specific family of transcription factors, has many stories to share when it comes to reproduction. Etv5 deficient mice show complex infertility phenotypes both in males and females. In males, the infertility phenotype exhibited by Etv5 deficiency is sexually dimorphic, and it involves both somatic cells and germ cells. In Etv5-/- female mice, the problem is more complicated by hormonal involvement. This review synthesizes old and new information on this versatile transcription factor-from the inadvertent discovery of its role in the testes to its newly discovered role in maintaining spermatogonial stem cells.
