Study on the correlation between chronic asymptomatic HBV carriers of yin asthenia constitution and genotypes of HLA-DRB1 and HLA DQA1 alleles.
- Author:
Jian-chun GUO
1
;
Li-na XIAO
;
Yun-hao XUN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Carrier State; Constitution and Bylaws; Female; Gene Frequency; Genotype; HLA-DQ alpha-Chains; genetics; HLA-DRB1 Chains; genetics; Hepatitis B, Chronic; genetics; Humans; Male; Middle Aged; Polymorphism, Genetic; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2012;32(8):1038-1041
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study on the correlation between chronic asymptomatic HBV carriers (ASC) of yin asthenia constitution and genotypes of HLA-DRB1 and HLA DQA1 alleles.
METHODSTotally 105 ASC were assigned to two groups according to their constitutions, i.e., the yin asthenia group (47 cases) and the non-yin asthenia group (58 cases). The genotypes of HLA-DRB1 and HLA DQA1 alleles were determined using PCR-SSP.
RESULTSThe gene frequency of HLA-DRB1 * 09 allele and HLA-DQA1 * 0301 allele (being 12.1% and 19.1%) were obviously lower in the yin asthenia group than in the non-yin asthenia group (being 27.8% and 39.7%, P < 0.05). The gene frequency of HLA-DRB1 * 11 allele and HLA-DQA1 * 0501 allele were obviously higher in the yin asthenia group (being 12.1% and 28.7%) than in the non-yin asthenia group (4.3% and 9.5%), showing statistical difference (P < 0.05, P < 0.01).
CONCLUSIONSHLA-DRB1 * 09 allele and HLA-DQA1 * 0301 allele might be the molecular bases for non-yin asthenia patients with ASC. HLA-DRB1 * 11 allele and HLA-DQA1 * 0501 allele might be the molecular bases for yin asthenia patients with ASC.
