Research progress on forkhead box protein O1 and bone metabolism.

Author: Linjing SHU ¹ ; Yingying WU ²
Author Information

1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
2. State Key Laboratory of Oral Diseases, Dept. of Implantology, West China Hospital of Stomatology, Sichuan Unive
Publication Type:Journal Article
Keywords: bone metabolism; forkhead box protein O1; osteoblasts; osteoclasts
MeSH: Bone and Bones; metabolism; Cell Proliferation; Forkhead Box Protein O1; Humans; Osteoblasts; Osteoclasts
From: West China Journal of Stomatology 2016;34(4):429-432
CountryChina
Language:Chinese
Abstract: Recent studies found that forkhead box protein O1 (FoxO1) does not only demonstrate important biological functions in cell proliferation, gluconeogenesis, energy metabolism, and oxidative stress, but it also plays a vital role in the remodeling process of bones. FoxO1 can regulate bone mass by affecting osteoblasts, osteoclasts, and precursor cells. In this article, we review the role of FoxO1 in bone metabolism and elucidate its underlying mechanism.