Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth and remodeling.
- VernacularTitle:缺氧诱导因子-1α信号通路在髁突软骨生长和改建中的作用机制
- Author:
Gaoli XU
1
;
Lili WU
1
;
Zhiwu WU
2
Author Information
- Publication Type:Journal Article
- Keywords: condylar cartilage; hypoxia-inducible factor-1α; hypoxic; static pressure
- MeSH: Cartilage; Chondrocytes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Signal Transduction
- From: West China Journal of Stomatology 2016;34(6):639-642
- CountryChina
- Language:Chinese
- Abstract: The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposed in normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in great difficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much as possible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response to hypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This review summarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilage repair.