Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth and remodeling.

VernacularTitle:缺氧诱导因子-1α信号通路在髁突软骨生长和改建中的作用机制
Author: Gaoli XU ¹ ; Lili WU ¹ ; Zhiwu WU ²
Author Information

1. School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China.
2. School of Stomatology, Zhejiang Chinese Medical University
Publication Type:Journal Article
Keywords: condylar cartilage; hypoxia-inducible factor-1α; hypoxic; static pressure
MeSH: Cartilage; Chondrocytes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Signal Transduction
From: West China Journal of Stomatology 2016;34(6):639-642
CountryChina
Language:Chinese
Abstract: The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposed in normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in great difficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much as possible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response to hypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This review summarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilage repair.