Research progress on bisphosphonate-related osteonecrosis of the jaws.

VernacularTitle:双膦酸盐相关性颌骨坏死
Author: Jian PAN ¹ ; Qizhang WANG ²
Author Information

1. State Key Laboratory of Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
2. State Key Laboratory of Oral Diseases, Dept. of Oral and Maxillofacial S
Publication Type:Journal Article
Keywords: bisphosphonates; jaws; osteonecrosis
MeSH: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Bone Resorption; Diphosphonates; Humans; Jaw; Risk Factors; Treatment Outcome
From: West China Journal of Stomatology 2017;35(1):29-36
CountryChina
Language:Chinese
Abstract: Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been widely used for treatment of several diseases. In recent years, dentists and oral and maxillofacial surgeons reported continuously increasing cases of bisphosphonate-related osteonecrosis of the jaws (BRONJ). This disease is clinically characterized by exposed bones, formation of sequestrum, pain, and halitosis. Provided that pathogenesis of BRONJ is unclear, effective treatments for this disease are currently unavailable. Thus, prevention plays an important role in the management of BRONJ. This review summarizes research progress on pathogenesis, risk factors, clinical characteristics, treatment, and prevention of this condition.