Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth.

Author: Yingzhu KANG ¹ ; Shujuan GUO ²
Author Information

1. State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
2. State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of St
Publication Type:Journal Article
Keywords: collagen phagocytosis; collagens metabolism; drug-induced gingival overgrowth; integrin α2β1
MeSH: Collagen; Gingiva; Gingival Overgrowth; Humans; Integrin alpha2beta1; Phagocytosis
From: West China Journal of Stomatology 2017;35(1):99-103
CountryChina
Language:Chinese
Abstract: Drug-induced gingival overgrowth (DIGO) is characterized by fibrous gingival hyperplasia and increased gingival volume. DIGO is histologically associated with proliferation of cells and deposition of extracellular matrices, particularly collagen. Integrin α2β1 is related to collagen phagocytosis and involved in the occurrence and progression of DIGO. This paper reviews the progress of research on the relationship between integrin α2β1 and DIGO.