Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice.
- Author:
Yong-ping ZHU
1
,
2
,
3
;
Zai-hao LONG
;
Ming-lan ZHENG
;
Ralf BINSACK
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Conditioning (Psychology); drug effects; Excitatory Amino Acid Antagonists; pharmacology; Magnesium; physiology; Male; Mice; Mice, Inbred ICR; Morphine; pharmacology; Motor Activity; drug effects; Phthalazines; pharmacology; Receptors, N-Methyl-D-Aspartate; antagonists & inhibitors
- From: Journal of Zhejiang University. Science. B 2006;7(12):998-1005
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice.
METHODSDifferent doses (1.25, 2.5 and 5 mg/kg, i.p.) of MRZ2/576 were used to evaluate the effect of MRZ2/576 on the acquisition and expression of CPP induced by morphine (5 mg/kg) in mice. In addition, we examined the locomotor activity of mice in conditioning and testing phase of CPP paradigm.
RESULTSMRZ2/576 alone could not establish place preference, but a 5 mg/kg dose of MRZ2/576 could block both acquisition and expression of morphine-induced CPP. In testing phase of CPP, there was no statistical difference for locomotor activity between the groups; injection of MRZ2/576 showed a dose-dependent decrease of locomotor activity on both control and morphine-treated mice, especially 5 mg/kg of MRZ2/576 significantly suppressed the locomotor activity of mice.
CONCLUSIONBased on the present results, we assume that MRZ2/576 can antagonize the rewarding effect of morphine, suggesting that this glycine site/NMDA receptor antagonist could be used to treat addictions due to its light side effect profile.
