Case control study on risk factors of congenital microtia.
- Author:
Jia-mei DU
1
;
Wan-hou GUO
;
Juan HAN
;
Hong-xing ZHUANG
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Child; Congenital Abnormalities; etiology; Ear Auricle; abnormalities; Female; Humans; Male; Maternal Exposure; Paternal Exposure; Pregnancy; Retrospective Studies; Risk Factors; Surveys and Questionnaires
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2006;41(2):107-111
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the risk factors associated with congenital microtia.
METHODSA case-control, retrospective study was performed. A total of 207 cases of congenital microtia and 209 age-frequently-matched controls were interviewed individually according to the uniform questionnaire. The questionnaire included: (1) Essential information about patients and their parents. (2) First trimester diseases and medication of mother. (3) Past gestation history of mother. (4) Family history and life style of the parent. The available data were analyzed by chi-square test and multivariate Logistic regression model.
RESULTSThe factors, such as gender (OR = 5.893), first trimester disease of mother (OR = 34.49) and medication (OR = 4.299), excessive drinking and smoking of father (OR = 4. 347, OR = 4.304), non-primiparous parity (OR = 9.524), abortion (spontaneous and induced, OR = 1.723), low-education of mother (OR = 2.275) were risk factors contributing to microtia in multivariate study. The factors, such as tea (OR = 0.179) were protective factors in multivariate study.
CONCLUSIONSMulti-risks factors are contributing to microtia. Preventive measures according to risk factors should be put forward.
