Expression and significance of interleukin-17 and its receptor in nasal polyps.
- Author:
Xin WANG
1
;
Zhen DONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Case-Control Studies; Female; Humans; Interleukin-17; metabolism; Male; Middle Aged; Nasal Polyps; metabolism; pathology; Receptors, Interleukin-17; metabolism
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2005;40(12):899-902
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression and distribution of interleukin-17 and interleukin 17 receptor (IL-17R) in nasal polyps and to probe into their significance in the pathology of nasal polyps.
METHODSThe methods of immunohistochemical staining and western blot were used to detect IL-17 and IL-17R in nasal polyps and controls.
RESULTSIn nasal polyp tissues, IL-17 expressed mainly in cytoplasm of plasm cell, less in prickle-cell layer of the epithelium and the acinus of the serous gland. In turbinates, IL-17 also expressed in the cytoplasm of the plasm cell, the prickle-cell layer of the epithelium and the acinus of the serous gland. The expression of IL-17 between nasal polyps and turbinates differed significantly (t = 2.237, 2.176, 2.246, P < 0.05, respectively). Both IL-17 and IL-17R displayed specific bands in nasal polyps and turbinates, but the bands of IL-17 and IL-17R in nasal polyps were stronger than those in turbinates.
CONCLUSIONSIL-17 may have an important role in the occurrence of nasal polyps by specific combination with IL-17R and over-expression in nasal polyps.
