Serum levels of HIF-1α, ET-1 and Ca(2+) in neonates with hypoxic pulmonary hypertension.
- Author:
Ying ZHOU
1
;
Le WANG
;
Ming-Xia LI
Author Information
- Publication Type:Journal Article
- MeSH: Blood Pressure; Calcium; blood; physiology; Endothelin-1; blood; Female; Humans; Hypertension, Pulmonary; blood; etiology; Hypoxia; complications; Hypoxia-Inducible Factor 1, alpha Subunit; blood; Infant, Newborn; Male; Pulmonary Artery; physiopathology
- From: Chinese Journal of Contemporary Pediatrics 2011;13(3):181-184
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes and significance of serum hypoxia-inducible factor-1α (HIF-1α), endothelin-1 (ET-1) and calcium (Ca(2+)) levels in neonates with hypoxic pulmonary hypertension (HPH).
METHODSSeventy-five neonates with HPH (29 mild, 25 moderate and 21 severe) and 22 hospitalized neonates with non-HPH (control group) were enrolled. Pulmonary artery systolic blood pressure (PASP) was measured by bedside echocardiography within 24 hrs after birth. Serum levels of HIF-1α and ET-1 were measured using ELASA. Serum Ca2+ concentrations were measured with ion selective electrode.
RESULTSSerum levels of HIF-1α and ET-1 in the HPH group increased significantly compared with those in the control group (P<0.01), and were positively related with PASP (Rhif-1α=0.75, P<0.01; Ret-1=0.56,P<0.05). Serum Ca2+ levels in neonates with severe HPH were significantly lower than those in the control group (P<0.05). There were no correlation between serum Ca2+ levels and PASP.
CONCLUSIONSSerum HIF-1α and ET-1 levels are positively related with PASP in neonates with HPH, suggesting that serum HIF-1α and ET-1 may be involved in the occurrence of neonatal HPH. Serum Ca2+ levels are reduced in severe neonates with HPH, suggesting that serum Ca2+ may play a role in the occurrence of severe HPH.
