P-selectin gene -2123 polymorphism in children with Henoch-Sch-nlein purpura.
- Author:
Jing LI
1
;
Yi-Bing WANG
;
Hua-Lin LIU
;
Yu-Hong JIANG
;
Wei LIU
;
Ya-Qiu WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Female; Humans; Male; P-Selectin; genetics; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Purpura, Schoenlein-Henoch; etiology; genetics
- From: Chinese Journal of Contemporary Pediatrics 2011;13(4):278-281
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether P-selectin gene -2123 polymorphism is associated with the pathogenesis of Henoch-Sch-nlein purpura (HSP) in children.
METHODSPolymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) is used to identify the distribution of allele and genotype frequencies of P-selectin gene promoter -2123 polymorphism in 86 children with HSP (including 40 cases of purpura nephritis) and 70 healthy controls.
RESULTSCompared with the healthy controls, the frequencies of GG genotype and G allele of P-selectin promoter -2123 in children with HSP increased significantly (P<0.05). There were no significant differences in P-selectin promoter -2123 genotype and allele frequencies between the patients with and without nephritis.
CONCLUSIONSP-selectin gene promoter -2123 polymorphism appears to be associated with the pathogenesis of HSP in children.
