Late endothelial function in children with coronary aneurysm due to Kawasaki disease.
- Author:
Chao DUAN
1
;
Zhong-Dong DU
;
Yu WANG
;
Li-Qun JIA
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Coronary Aneurysm; etiology; physiopathology; Endothelium, Vascular; physiopathology; Female; Humans; Male; Mucocutaneous Lymph Node Syndrome; complications; physiopathology; Vasodilation
- From: Chinese Journal of Contemporary Pediatrics 2011;13(5):373-376
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the late endothelial function in children with coronary aneurysm due to Kawasaki disease (KD).
METHODSThirty-one children with coronary aneurysms due to KD who had the disease course for more than 1 year and twenty-one age-matched healthy children were enrolled. Brachial artery endothelium-dependent and -independent flow-mediated dilation (FMD), carotid arterial stiffness index (SI) and intima-media thickness (IMT) were measured by high-frequency ultrasound.
RESULTSThere were 9 cases of medium and 22 cases of giant coronary aneurysms in the KD group. Twelve KD patients had evidence of myocardial ischemia. Compared to the normal controls, the endothelium-dependent FMD decreased (P<0.05), the carotid arterial SI increased (P<0.05), and the carotid arterial intima-media thickness increased significantly (P<0.05) in children with coronary aneurysms due to KD. The endothelium-dependent FMD decreased more significantly in 12 KD patients with myocardial ischemia than in those without any evidence of myocardial ischemia (P<0.05).
CONCLUSIONSLate endothelial dysfunction exists in children with coronary aneurysms due to KD, especially in those with myocardial ischemia.
