Effect of Aike Mixture on the inflammatory infiltration in patients with chronic prostatitis type III A.
- Author:
Min-Jian ZHANG
1
;
Jian-Fei WENG
;
Ya-Lei SHI
;
Wan-Jun CHENG
;
Xiao-Jun RUAN
;
Qiu-Yong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Chronic Disease; Drugs, Chinese Herbal; adverse effects; therapeutic use; Fibroblasts; pathology; Humans; Hyperplasia; Inflammation; drug therapy; pathology; Male; Middle Aged; Prostatitis; classification; drug therapy; pathology
- From: Chinese journal of integrative medicine 2011;17(1):26-30
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo observe the effect of Aike Mixture (AKM) on prostatic inflammatory infiltration in patients with chronic prostatitis type III A (III A-CP/CPPS) and evaluate its anti-inflammatory action. METHODS METHODS: A total of 60 patients with III A-CP/CPPS suitable to operation and differentiated as Chinese medicine: Gan qi stagnancy syndrome type were selected. They were assigned with the random number table to two groups equally. Before operation, the patients in the treated group were administered with Proscar combined with AKM, but those in the control group treated with Proscar only. Suprapubic transvesical prostatectomy was performed two weeks later, and prostatic pathological examination was conducted.
RESULTSGrading of: inflammatory cell infiltration showed that the mean grade in the treated group was 0.78 ± 0.90 grades, which was significantly lower than that in the control group 1.68 ± 0.87 grades (P<0.05). However, the two groups were not different in the grades of fibroblast proliferation (1.50 ± 0.70 grades vs 1.62 ± 0.87 grades, P>0.05).
CONCLUSIONAKM could suppress the inflammatory cell infiltration, be an effective and safe remedy for the treatment of IIIA-CP/CPPS of Gan-qi stagnancy syndrome type, and worthy for spreading in clinical use.