Research progress studies on pharmacology and pharmacokinetics of ligustilide.
- Author:
Ai-Hua ZUO
1
;
Li WANG
;
Hong-Bin XIAO
Author Information
1. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China.
- Publication Type:Journal Article
- MeSH:
4-Butyrolactone;
analogs & derivatives;
pharmacokinetics;
pharmacology;
Angelica sinensis;
chemistry;
Animals;
Drugs, Chinese Herbal;
pharmacokinetics;
pharmacology;
Humans;
Ligusticum;
chemistry
- From:
China Journal of Chinese Materia Medica
2012;37(22):3350-3353
- CountryChina
- Language:Chinese
-
Abstract:
Ligustilide is contained highly or around 1% in such umbelliferous plants as Angelica sinensis and Ligusticum chuanxiong, is one of main bioactive constituents. It shows many pharmacological activities related to their efficacy. At present, ligustilide has attracted extensive attention and more and more studies have been reported, indicating that it is a promising compound. This essay summarizes the progress of pharmacological effects of ligustilide on neuroprotection, vasodilatation, anti-caner and anti-tumor, analgesia and anti-inflammation, and pharmacokinetics including absorption, distribution, metabolism and excretion, providing basis for further studies and development of ligustilide.
