Stability of PEGylated puerarin under different storage conditions.
- Author:
Xin-Yi LIU
1
;
Da-Xiong XIANG
;
Jian-He LI
;
Xiong-Bin HU
;
Zu-Guang YE
Author Information
- Publication Type:Journal Article
- MeSH: Drug Stability; Drug Storage; Isoflavones; chemistry; Light; Polyethylene Glycols; chemistry; Temperature
- From: China Journal of Chinese Materia Medica 2012;37(22):3391-3394
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the stability of PEGylated puerarin (PEG-PUE), in order to provide experimental basis for storage conditions of PEGylated puerarin.
METHODFirst, a method for determining the content of PEG-PUE was established. Next, a system study was conducted for the stability of PEG-PUE affected by different factors such as temperature, humidity, light and light avoidance.
RESULTPEG-PUE was severely degraded under the conditions of high temperature, high humidity and light. It was also seriously degraded under high temperature.
CONCLUSIONPEG-PUE shall be stored under low temperature and in a dark and dry environment.
