Effect of borneol on intestinal absorption of muscone in rats.
- Author:
Liang ZOU
1
;
Jun-Zhi LIN
;
Hui-Ling HU
;
Ying WANG
;
Ping WANG
;
Gang ZHAO
;
Zhan-Guo WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bornanes; pharmacology; Cycloparaffins; pharmacokinetics; Drug Interactions; Drugs, Chinese Herbal; pharmacokinetics; pharmacology; Intestinal Absorption; drug effects; Intestines; drug effects; metabolism; Male; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2012;37(22):3490-3493
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influence of borneol on intestinal absorption of muscone in rats.
METHODAn in situ intestinal circulation perfusion experiment was used to study the changes in intestinal absorption kinetics of muscone before and after being compatible with borneol.
RESULTCompared with the muscone group (MG), the absorption rate constants (Ka), the half-life period (T1/2) and the absorption rate (A) of muscone in the borneol + muscone group (BMG) were on the rise, but with no significant difference; after being compatible with borneol for a long period, Ka, T1/2 and A in the last borneol on muscone group (LBMG) increased, with significant difference (P < 0.05). in duodenum, LBMG showed better effects than MG (T1/2, P < 0.05); and so did in jejunum (Ka, P < 0.05; T1/2, P < 0.05); in ileum, there was no significant statistical difference between LBMG and MG.
CONCLUSIONBorneol can promote the intestinal absorption of muscone in rats to some extent.
