Stable life predection for honeysuckle by initial average rate stability test.
- Author:
Zhi-Ping XUE
1
;
Jin-Mei WANG
;
Jie LIU
;
Wen-Yi KANG
Author Information
- Publication Type:Journal Article
- MeSH: Chlorogenic Acid; analysis; Chromatography, High Pressure Liquid; Drug Stability; Lonicera; chemistry; Temperature
- From: China Journal of Chinese Materia Medica 2012;37(21):3179-3181
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the content change of chlorogenic acid in honeysuckle under different temperature, and predict its term of validity at room temperature.
METHODThe content of chlorogenic acid was assayed by HPLC. The activation energy E(a) and the decomposition rate constant K were calculated by initial average rate stability tests and the prediction was carried out.
RESULTThe stable life of honeysuckle has been determined as 1.29 years.
CONCLUSIONThe initial average rate stability test was used to predict stable life of honeysuckle, and the results are credible. Higher temperature should be avoided for honeysuckle store, and room temperature should guarantee its quality during storage.
