Stable life predection of Hangbaiju and Gongju by classic constant temperature accelerated test method.
- Author:
Da-Peng ZHANG
1
;
Zhi-Ping XUE
;
Jie LIU
;
Wen-Yi KANG
Author Information
- Publication Type:Journal Article
- MeSH: Chlorogenic Acid; analysis; Chromatography, High Pressure Liquid; Chrysanthemum; chemistry; Drug Stability; Drugs, Chinese Herbal; chemistry; Temperature
- From: China Journal of Chinese Materia Medica 2012;37(21):3182-3184
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the stability of chlorogenic acid, cynaroside and 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju and to predict their term of validity.
METHODHangbaiju and Gongju were incubated in an environmental chamber at different temperatures and relative humidities. After the incubation, quantitative determination of chlorogenic acid, cynaroside, 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju were measured by HPLC. The effective period of the preparation was calculated according to Arrhinius index law. Quantitative determination of 3,5-O-discaffeoylquinc acid, cynaroside, chlorogenic acid in Hangju and Gongju were analyzed by HPLC.
RESULTThe stable life of Hangbaiju has been determined as 2.25 years. The stable life of Gongju has been determined as 4.31 years.
CONCLUSIONThe high temperature is not conducive to the stability of Hangbaiju and Gongju, which needs to be placed in a dark and cool place.
