Application of BeWo cell model in studies on placental transport mechanism.
- Author:
Jie GUO
1
;
Dian-Rong SONG
Author Information
1. The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medince, Tianjin 300150, China. guojie76@126.com
- Publication Type:Journal Article
- MeSH:
Biological Transport;
Choriocarcinoma;
metabolism;
Female;
Humans;
Placenta;
metabolism;
Pregnancy;
Tumor Cells, Cultured;
metabolism;
Uterine Neoplasms;
metabolism
- From:
China Journal of Chinese Materia Medica
2012;37(21):3193-3197
- CountryChina
- Language:Chinese
-
Abstract:
As placenta barrier controls material exchanges between mother and fetus during pregnancy, studies on the placental transport mechanism of drugs is of great importance to analyze the efficacy, safety and toxicity of drugs. BeWo cells are derived from human choriocarcinomas, which can form monolayer trophoblast cells to offers an efficient placenta barrier in vitro for estimating nutrient and drug intake, efflux and transport. This essay focuses on the establishment and characteristics of BeWo cell model, and the advance on studies on nutrient and drug intake, efflux and transport mechanism by applying the model.
