Advance in study on pharmacological mechanisms of Qingkailing injection in intervention of ischemic cerebral injury.
- Author:
Yin-Ying CHEN
1
;
Zhong WANG
Author Information
1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. fanok77@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Blood-Brain Barrier;
drug effects;
Brain Ischemia;
drug therapy;
Cell Adhesion Molecules;
physiology;
Cytokines;
biosynthesis;
Drugs, Chinese Herbal;
pharmacology;
therapeutic use;
Humans;
Injections;
Nerve Growth Factors;
physiology
- From:
China Journal of Chinese Materia Medica
2012;37(21):3198-3202
- CountryChina
- Language:Chinese
-
Abstract:
As a severe threat to human health, ischemic brain injury has a very complex pathological mechanism involving excitotoxic amino acids, oxygen free radical formation, nitric oxide (NO), Ca2+ overload and inflammation. Traditional Chinese medicine Qingkailing injection have shown good clinical efficacy in the treatment of cerebrovascular disease, and thus it is very significant to studies on its pharmacological mechanism. This essay summarizes relevant studies on pharmacological mechanism of a new compound traditional Chinese medicine Jingzhiqiangkailing (JZQKL) injection in treatment on cerebral ischemia, and explains the pharmacological mechanism of its single effective compounds and their compatibility in treatment of schemic brain injury in the aspects of regulating inflammatory response, neurotrophic factors, vascular protection, blood-brain barrier (BBB) protection and others, and thus providing information for further studies.
