In vitro dissolution of forsythin in Forsythia suspensa powder of different particle diameter.
- Author:
Xin-Yi LIU
1
;
Shui-Han ZHANG
;
Jian-He LI
;
Da-Xiong XIANG
;
Li-Dan YI
;
Zu-Guang YE
Author Information
- Publication Type:Journal Article
- MeSH: Bridged Bicyclo Compounds, Heterocyclic; chemistry; Chromatography, High Pressure Liquid; Forsythia; chemistry; Furans; chemistry; Particle Size; Powders
- From: China Journal of Chinese Materia Medica 2012;37(21):3233-3235
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the in vitro dissolution of forsythin in Forsythia suspensa powder of different particle diameter, in order to give guidance to the grinding process.
METHODHPLC was used to determine the in vitro dissolution quantity and dissolution velocity of forsythin coarse powder, fine powder and ultramicroscopic powder.
RESULTThe dissolution curves of Forsythia suspensa coarse powder, fine powder and ultramicroscopic powder were basically inconformity to Weibull distribution. Specifically, T50 was 11.8, 10.5 and 6.8 min, respectively, and Q45 was 78.22%, 81.91% and 90.76%, respectively.
CONCLUSIONThe superfine milling process can significantly increase the dissolution quantity and dissolution velocity of forsythin.
