Research progress of effect of anti-diabetic traditional Chinese medicines based on regulation of glucose metabolic enzyme.
- Author:
Liu JI
1
;
Xin-Qiang TANG
;
Jin-Yong PENG
Author Information
1. College of Pharmacy, Dalian Medical University, Dalian 116044, China. liu1987517@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetes Mellitus;
drug therapy;
enzymology;
metabolism;
Drugs, Chinese Herbal;
analysis;
therapeutic use;
Enzyme Activators;
analysis;
therapeutic use;
Enzyme Inhibitors;
analysis;
therapeutic use;
Glucose;
metabolism;
Glucose-6-Phosphatase;
metabolism;
Glycogen Synthase Kinase 3;
metabolism;
Humans;
Hypoglycemic Agents;
analysis;
therapeutic use;
alpha-Glucosidases;
metabolism
- From:
China Journal of Chinese Materia Medica
2012;37(23):3519-3525
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a global threat threatening human health in the world, with an increasing incidence rate in recent years. The disorder of glucose metabolism is one of the major factors. As relevant glucose metabolic enzymes such as alpha-glucosidase, glucose-6-phosphatase (G-6-P), glycogen phosphorylase (GP) and glycogen synthase kinase-3 (GSK-3) get involved in and control the process of glucose metabolism, the regulation of the activity of glucose metabolic enzymes is of significance to the treatment of diabetes. Traditional Chinese medicines (TCMs) have been widely researched because of their low toxicology and high efficiency, and many extracts and components from TCMs have been proven to be regulators of glucose metabolic enzymes. Compared with anti-diabetic western medicines, anti-diabetic TCMs feature safety, reliability and low price. This essay summarizes the anti-diabetic effect of TCMs on regulating glucose metabolic enzymes.
