Association of genetic polymorphism in the DNA repair gene XRCC1 with susceptibility to lung cancer in non-smoking women.
- Author:
Ming-chuan LI
1
;
Ze-shi CUI
;
Qin-cheng HE
;
Bao-sen ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; etiology; genetics; Adult; Aged; Air Pollution, Indoor; adverse effects; Carcinoma, Squamous Cell; genetics; Case-Control Studies; Cooking; DNA-Binding Proteins; genetics; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms; etiology; genetics; Middle Aged; Polymorphism, Genetic; Risk Assessment; Smoking; adverse effects; X-ray Repair Cross Complementing Protein 1
- From: Chinese Journal of Oncology 2005;27(12):713-716
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the relationship between the XRCC1 polymorphism and susceptibility to lung cancer in non-smoking female on the basis of a hospital-based case-control study.
METHODSGenotypes were determined by PCR-restriction fragment length polymorphism in 50 patients with lung cancer and 50 controls. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression model to study the relationship between different genotypes and risk of lung cancer in non-smoking women. Furthermore, a multiplicative interaction between exposure to cooking oil smoke and the variant XRCC1 399Gln allele on risk of lung adenocarcinoma was evaluated.
RESULTSIndividuals carrying Gln/Gln genotype were at an increased risk to suffer from lung adenocarcinoma as compared with those with the Arg/Arg genotype (OR: 14.12; 95% CI: 2.14 approximately 92.95, adjusted for age and cooking oil smoke). The OR of lung adenocarcinoma for the variant XRCC1 399Gln allele with exposure to cooking oil smoke was 6.29 (95% CI 1.99 approximately 19.85).
CONCLUSIONThe above described findings indicate that Arg 399Gln polymorphism in the XRCC1 is associated with risk of lung adenocarcinoma but not with risk of squamous-cell carcinoma of the lung in non-smoking women.
