Expression of P-gp, GST-pi and Topo II alpha in gastric and colorectal cancers and their clinical significance.
- Author:
Wan-yuan CHEN
1
;
Wei-min MAO
;
Li ZHAO
;
Guo-ping CHEN
;
Yue SHU
;
Yu-fei SHEN
;
Xin-hai ZHU
;
Yu XIA
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; biosynthesis; genetics; Adenocarcinoma; metabolism; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; biosynthesis; genetics; Colorectal Neoplasms; metabolism; DNA Topoisomerases, Type II; biosynthesis; genetics; DNA-Binding Proteins; biosynthesis; genetics; Drug Resistance, Neoplasm; Female; Gastrointestinal Neoplasms; metabolism; Glutathione S-Transferase pi; biosynthesis; genetics; Humans; Immunohistochemistry; Male; Middle Aged; Stomach Neoplasms; metabolism
- From: Chinese Journal of Oncology 2005;27(12):738-740
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression and clinical significance of P-gp, GST-pi and Topo II alpha in gastric and colorectal cancers.
METHODSThe expression of P-gp, GST-pi and Topo II alpha in 83 cases with gastric or colorectal cancer were examined by immunohistochemistry S-P.
RESULTSThe positive expression rates of P-gp, GST-pi, Topo II alpha in normal tissue and gastric and colorectal cancers were 69.9%, 65.1%, 50.6% and 83.1%, 85.5%, 45.8%, respectively. The positive rates of P-gp and GST-pi in gastric and colorectal cancer were significantly higher than those in normal gastric and colorectal tissue (P < 0.05). The expression of Topo II alpha in poorly differentiated cancers was significantly higher than that in well-and moderately differentiated cancers. There was no correlation between other items and clinicopathological parameters (P > 0.05).
CONCLUSIONP-gp, GST-pi and Topo II alpha play important role in multidrug resistance. Their mechanisms of drug resistance were different. The detection of expression of P-gp, GST-pi and Topo II alpha has an important guiding significance in chemotherapy for gastric and colorectal cancers.
