A randomized trial comparing oxaliplatin plus vinorelbine versus cisplatin plus vinorelbine for the treatment of patients with advanced non-small-cell lung cancer.
- Author:
Xiang-ru ZHANG
1
;
Mei HOU
;
Jing-dong SUN
;
Jian-fei GAO
;
Yun-zhong ZHU
;
Da-wei PENG
;
Yi-ping ZHANG
;
Jia CHEN
;
Jun-lan YANG
;
Jun LIANG
;
Ping-hui WANG
;
Da-tong CHU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Carcinoma, Non-Small-Cell Lung; drug therapy; Cisplatin; administration & dosage; Drug Administration Schedule; Female; Humans; Lung Neoplasms; drug therapy; Male; Middle Aged; Organoplatinum Compounds; administration & dosage; Quality of Life; Treatment Outcome; Vinblastine; administration & dosage; analogs & derivatives
- From: Chinese Journal of Oncology 2005;27(12):743-746
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the difference of efficacy, side-effects and quality of life in advanced non-small-cell lung cancer (NSCLC) patients treated with oxaliplatin plus vinorelbine or cisplatin plus vinorelbine.
METHODSEligible patients were randomly assigned to NL (oxaliplatin + vinorelbine) group and NP (cisplatin + vinorelbine) group in a 2:1 ratio. In the NL group, 70 evaluable cases were treated with oxaliplatin 130 mg/m(2) i.v. on day 2, and vinorelbine 25 mg/m(2) i.v. on days 1 and 8 in 21 days per cycle. In the NP group, 32 evaluable cases were treated with cisplatin 80 mg/m(2) i.v. divided to 2 - 3 days dosing, 21 days per cycle, and vinorelbine administered by the same way as in the NL group. The response rate, time to progression (TTP), one-year survival, side-effects and the quality of life were observed.
RESULTSThe response rate was 35.7% vs. 43.8% (P = 0.4), median TTP was 4.7 months vs. 5.5 months (P = 0.6), one-year survival rate was 38.5% vs. 58.6% (P = 0.07) in the NL and NP groups, respectively. Grade I-II neuro-sensory toxicity occurred significantly more frequent in NL group than in NP group (68.4% vs. 36.4%, P = 0.0017). However, Grade I-II granulocytopenia was significantly less occurred in NL group than in NP group (49.4% vs. 70.6%, P = 0.037). There was no statistically difference between the two groups regarding quality of life.
CONCLUSIONDue to good efficacy and tolerability, the NL regimen offered a new candidate for treating advanced NSCLC.
