Significance of EGFR and p-ERK expression in nasopharyngeal carcinoma.
- Author:
Shu-sen WANG
1
;
Zhong-zhen GUAN
;
Yan-qun XIANG
;
Bo WANG
;
Tong-yu LIN
;
Wen-qi JIANG
;
Li ZHANG
;
Hui-zhong ZHANG
;
Jing-hui HOU
Author Information
- Publication Type:Journal Article
- MeSH: Age Factors; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinases; metabolism; Nasopharyngeal Neoplasms; metabolism; pathology; Neoplasm Staging; Proportional Hazards Models; Receptor, Epidermal Growth Factor; metabolism; Sex Factors; Survival Rate
- From: Chinese Journal of Oncology 2006;28(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of EGFR and p-ERK in nasopharyngeal carcinoma (NPC) and investigate their clinical significance.
METHODSImmunohistochemistry LSAB method was adopted to detect the expression of EGFR and p-ERK. Statistical analysis was performed using SPSS statistical software package (10.0) to correlate their expression with clinical characteristics and prognosis.
RESULTSPositive staining for EGFR was observed in 39 of 55 cases (70.9%). The EGFR expression was correlated with clinical stage and gender. EGFR expression was correlated with poorer overall survival (OS) and shorter time to progression (TTP). Positive staining for p-ERK was observed in 29 of 55 cases (52.7%). There was a statistically significant association between positive p-ERK expression and advanced clinical stage. Positive p-ERK expression was correlated with poorer OS, disease-free survival (DFS) and TTP. EGFR expression was correlated with the expression of p-ERK. On multivariate analysis, age over 50 years was an independent poor prognostic factor for NPC. Both EGFR and p-ERK were not independent prognostic factors for NPC.
CONCLUSIONExpressions of EGFR and p-ERK are detected in NPC. Their abnormally high expression signifies poor prognosis in NPC patients.
