Association between genetic polymorphism in STK15 and risk of colorectal cancer in a Chinese population.
- Author:
Wen-jie ZHANG
1
;
Xiao-ping MIAO
;
Tong SUN
;
Xue-mei ZHANG
;
Shi-ning QU
;
Wen TAN
;
Ping XIONG
;
Rong ZHENG
;
Dong-xin LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Amino Acid Substitution; Aurora Kinase A; Aurora Kinases; Case-Control Studies; Colonic Neoplasms; enzymology; genetics; pathology; Confidence Intervals; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Neoplasm Staging; Odds Ratio; Polymorphism, Single Nucleotide; Protein-Serine-Threonine Kinases; genetics; metabolism; Rectal Neoplasms; enzymology; genetics; pathology; Risk Factors
- From: Chinese Journal of Oncology 2006;28(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis case-control study was designed to detect the association between STK15 Phe31Ile polymorphism and colorectal cancer.
METHODSGenotypes were determined in 283 patients with colorectal cancer and 283 controls. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression model.
RESULTSThe frequency of the STK15 Ile/Ile genotype was significantly higher in cancer cases than in controls (50.2% vs. 36.8%; P = 0.02). Subjects with the Ile/Ile genotype had an increased risk for the occurrence of colorectal cancer compared with those with the STK15 Phe/Phe genotype (adjusted OR, 1.92; 95% CI, 1.13 - 3.27). No significant association was observed between this STK15 polymorphism and risk of metastasis of the cancer.
CONCLUSIONThese findings suggest that STK15 Phe/Ile polymorphism may be a genetic susceptibility factor for colorectal cancer among Chinese.
