Prognostic factors identified by Cox multivariate analysis of surgically treated 1018 laryngeal cancer patients.
- Author:
Qiang DU
1
;
Wen-yue JI
;
Chao GUAN
;
Qing-yun XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Laryngeal Neoplasms; mortality; pathology; surgery; Laryngectomy; Lymph Nodes; pathology; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Proportional Hazards Models; Salvage Therapy; Survival Rate; Vocal Cords; physiopathology
- From: Chinese Journal of Oncology 2006;28(3):211-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the prognostic factors of 1018 patients with laryngeal cancer treated surgically.
METHODSAll patients were treated surgically for laryngeal cancer from 1984 to 1996. A total of 16 clinical factors was studied by univariate analysis and Cox multivariate model.
RESULTSThe follow-up rate was 93.5% over 5 years. The overall cumulative survival rate was 79.1% at 3 years, 70.2% at 5 years. The 5-year survival rate of T1N0 is the highest, followed by T1N+, T2N0, T3N0, T4N0, T2N+, T4N+, and T3N+. In univariate analysis, the survival was related to patient age, mobility of vocal cords, preoperative T status, preoperative N status, preoperative UICC stage, postoperative T status, postoperative N status, postoperative UICC stage, topographic location of the tumor and tumor size. In Cox multivariate modal, only postoperative N status, mobility of vocal cords and tumor size were independent prognostic factors.
CONCLUSIONIndependent prognostic factors for patients with laryngeal cancer after curative resection are postoperative N stage, mobility of vocal cords as well as tumor size. Postoperative follow-up and salvage surgery in time should be attached with importance to improve the survival of patients with laryngeal cancer.
